Causes of abnormal number of teeth in your/your child’s dentition

A typical human being has 20 deciduous (or milk, primary) teeth, consisting of 4 incisors, 2 canines, and 2 molars in each jaw (upper and lower). This is followed by the permanent dentition (or secondary dentition), which consists of 4 incisors, 2 canines, 4 premolars, and 6 molars in each jaw, making up a total of 32teeth in a typical adult.


If a person has less than 20 deciduous teeth or 32 permanent teeth (not including those that has been extracted or those that are impacted), the condition is termed “hypodontia”, or “oligodontia”. If there is complete absence of teeth in one or both dentitions, it is called “anodontia”. Hypodontia is:

  • More common in permanent dentition
  • More common in females
  • Can be symmetrical, ie if the 3rd molar on the right side is missing, the 3rd molar on the left side is also missing; or haphazard without a discernible pattern
  • Third molars, upper lateral incisors, and lower 2nd premolars are the most frequent teeth involved with hypodontia in the symmetrical form.


Causes of hypodontia:

1. Related to genes:

it is found that missing teeth can be inherited in families with mutations in the MSX1 gene on chromosome 4, in which missing third molars and second premolars are the most common finding. Missing molars can also be a result of mutation in the PAX9 gene on chromosome 14.

2. Related to environmental factors:

Missing teeth have been reported to be associated with low birth weight, multiple births, and increased maternal age. Rubella infection and thalidomide can also affect the development of the fetus and lead to missing teeth.

3.  Related to some syndromes/conditions

i) Cleft lip and palate

Cleft lip

ii) Hypohydrotic ectodermal dysplasia

This syndrome is rare and is characterized by congenital absence of ectodermal structures. In other words, affected patients will have severe hypodontia and even anodontia, smooth dry skin with fine scarce hair, and partial or total absence of sweat glands. These patients are unable to tolerate heat. Some have a few teeth present, but their eruption can be delayed or their shape deformed.

Down syndrome child

iii)Down syndrome (Trisomy 21)

A Down syndrome child, is characterized by other symptoms such as decreased muscle tone at birth of the whole body, short stocky stature and limbs, short fingers, small upward-slanting eyes, high and narrow roof of the palate,  a flattened nose appearance, and many more.

iv) Crouzon syndrome

Also known as the branchial arch syndrome, it is a condition whereby there is craniosynostosis, which is the early fusion of bony plates of the skull, resulting in abnormal growth. These patients have widely separated eyes (hypertelorism), exophthalmos (eyes appear bulging out of their sockets), insufficient growth of the upper jaw resulting in a relative protrusion of the lower jaw, giving the face a concave profile.

v) Ellis-van Creveld syndrome

Other features found in these patients are dwarfism, extra fingers (polydactyly), cleft lip or palate, small peg-shaped teeth, and abnormally spaced teeth

vi) Oral-facial-digital syndrome

As the name suggests, there is associated cleft palate (oral), under-development of the nose (facial), and abnormal finger forms (digital)


What can be done if I have hypodontia?

The treatment options for hypodontia depends on multiple factors, such as number of tooth missing, site of missing tooth, available bone and ideal bone condition (for placing implants) etc. It can be a complex process involving a multidisplinary input from the paediatric dentist, orthodontist, and prosthodontist. Missing molars, especially the 3rd molars, do not have to be replaced. Sometimes there can be several teeth missing, but all the present teeth are arranged neatly together and can function as any other normal human being. In such cases, no treatment is necessary.

orthodontic treatment

In people with general spacing between teeth due to several teeth missing, they can consider application of orthodontics to push certain teeth together, to make space where a denture or other prosthesis such as implants or bridges can be fabricated to fill up that space later.
Hypodontia is often associated with small teeth. Such small teeth may be conical shaped, or merely smaller in size to a normal tooth. In such a case, masking of the tooth using composite material is strongly advocated.

Patients with severe hypodontia or anodontia can have a partial or complete denture done, with implants as part of the treatment protocol at a later age, when the development of the bone is complete. Of course, this means that dentures will have to be replaced as the child grows. Another problem with this alternative is the child’s limited compliance in the process of making dentures, which has to be repeated each time a new denture is indicated, and the willingness to wear a denture itself.

Hyperdontia will be further discussed in “Causes of abnormal number of teeth in your/your child’s dentition-Part II”.

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